PHOSPHOLIPID ANTIBODY (APLA) IgM – ES127
🧬 Recent Immune Activity Marker
₹649
MRP ₹750
Sample Time: 4:30 PM
Report: Same Day
Sample Type: Blood (Serum)
Test Code: ES127
Report: Same Day
Sample Type: Blood (Serum)
Test Code: ES127
About this Test:
The Phospholipid Antibody (APLA) IgM test detects IgM-type antibodies that target cell membrane phospholipids. While IgG indicates chronic risk, IgM often appears earlier and can indicate a recent immune response or infection-triggered autoimmunity.
✔ APS Screening: Part of the core panel to diagnose Antiphospholipid Syndrome (APS).
✔ Clot Investigation: Used to evaluate unexplained Deep Vein Thrombosis (DVT) or Pulmonary Embolism (PE).
✔ Pregnancy Loss: Investigates causes of recurrent early miscarriages.
✔ Differentiation: Helps distinguish between a persistent autoimmune condition and a temporary reaction.
The Phospholipid Antibody (APLA) IgM test detects IgM-type antibodies that target cell membrane phospholipids. While IgG indicates chronic risk, IgM often appears earlier and can indicate a recent immune response or infection-triggered autoimmunity.
✔ APS Screening: Part of the core panel to diagnose Antiphospholipid Syndrome (APS).
✔ Clot Investigation: Used to evaluate unexplained Deep Vein Thrombosis (DVT) or Pulmonary Embolism (PE).
✔ Pregnancy Loss: Investigates causes of recurrent early miscarriages.
✔ Differentiation: Helps distinguish between a persistent autoimmune condition and a temporary reaction.
Why Test for APLA IgM?
In Antiphospholipid Syndrome (APS), the body's immune system attacks phospholipids, making blood sticky and prone to clotting. While IgG antibodies are the strongest predictor of clotting, testing for IgM is crucial because:
- Early Detection: IgM is the first antibody isotype the body produces. It can signal the onset of autoimmune activity.
- Isolated Positivity: Some patients with clinical symptoms of blood clots or pregnancy loss may test negative for IgG but positive for IgM. Without this test, their diagnosis would be missed.
- Transient vs. Persistent: IgM antibodies can sometimes spike temporarily due to infections or medications. If you test positive for IgM, doctors will repeat the test in 12 weeks. If it stays positive, it confirms APS; if it disappears, the risk was temporary.
Symptoms warranting this test:
- Unexplained blood clots in legs (swelling, pain) or lungs (shortness of breath).
- Recurrent miscarriages (especially before the 10th week).
- Stroke or TIA (mini-stroke) at a young age.
Frequently Asked Questions (FAQ)
Q1: What is the difference between APLA IgM and IgG?
IgM antibodies are often first responders and can indicate a recent immune event or be less specific. IgG antibodies typically indicate a long-term, established autoimmune condition with a higher risk of clotting. Doctors test both to get a complete picture.
IgM antibodies are often first responders and can indicate a recent immune event or be less specific. IgG antibodies typically indicate a long-term, established autoimmune condition with a higher risk of clotting. Doctors test both to get a complete picture.
Q2: If I am positive for IgM, do I have APS?
Not definitely. IgM can sometimes be positive due to infections (like viruses) or drugs. To confirm the syndrome, the test must be repeated after 12 weeks. If it is still positive, then APS is diagnosed.
Not definitely. IgM can sometimes be positive due to infections (like viruses) or drugs. To confirm the syndrome, the test must be repeated after 12 weeks. If it is still positive, then APS is diagnosed.
Q3: How does this affect pregnancy?
APLA antibodies can interfere with the placenta's development and blood flow. A positive result helps doctors prescribe treatments (like blood thinners) to support a healthy pregnancy and prevent miscarriage.
APLA antibodies can interfere with the placenta's development and blood flow. A positive result helps doctors prescribe treatments (like blood thinners) to support a healthy pregnancy and prevent miscarriage.
Q4: Is fasting required?
No, you do not need to fast for the APLA IgM test.
No, you do not need to fast for the APLA IgM test.
Q5: Can I get the report the same day?
Yes, at Sanovra Lab, if you provide the sample by 4:30 PM, we process and release the report by the evening of the same day.
Yes, at Sanovra Lab, if you provide the sample by 4:30 PM, we process and release the report by the evening of the same day.